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Bone morphogenetic protein 4 promotes vascular remodeling in hypoxic pulmonary hypertension

David Frank1, Joyce Johnson, Mark de Caestecker

  • 1Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.

Chest
|December 24, 2005
PubMed
Abstract

No abstract available in PubMed .

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl hydroxylase and factor...

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