Changing patterns of sexual behaviour in the era of highly active antiretroviral therapy

To describe changing patterns of sexual behaviour in the era of highly active antiretroviral therapy among gay/bisexual men in Europe, Canada, USA and Australia.

While there has been a substantial increase in high-risk sexual behaviour among gay men since 1996, this now appears to be levelling off in some cities. Overall the empirical evidence does not support the suggestion that taking highly active antiretroviral therapy or having an undetectable viral load leads to risky sexual behaviour among people with HIV. Nor can HIV treatment optimism alone explain the recent increase in high-risk sexual behaviour. Since 1996, an increasing number of gay men have begun to use the Internet to look for sexual partners. By serosorting on the Internet, HIV-positive men are more likely to meet online, rather than off-line, other HIV-positive men for unprotected sex. While serosorting does not present a risk of HIV transmission to an uninfected person, it does present a risk of other sexually transmitted infections and co-infection with resistant virus for HIV-positive men themselves. This review also explores emerging behaviours such as barebacking and strategic positioning as well as the role of crystal meth and Viagra.

The review reminds us of the complexity of human and sexual behaviour. Among gay men, sexual behaviour in the era of highly active antiretroviral therapy has been characterized by risk reduction and stabilization as well as increasing risk. These changing patterns provide a new challenge as well as new opportunities for HIV prevention.