[Removal of plasma lipids by selective filtration]

We herein describe a new depth filter media which exhibits selective adsorption properties for lipids of plasma on Zeta Plus Del I (Cuno Europe). Lipids plug chromatographic columns and filter during plasma fractionnation and cause solution instability for the final product. Several parameters which could affect the lipid removal efficiency on Zeta Plus Del I have been investigated: prefiltration, contact time, ionic strength, pH, and temperature. The maximum percentage of total lipids eliminated, in the better operating conditions was 68%. This method has proven to be efficient for the treatment of plasmatic lipids and can be easily incorporated in an industrial process.