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Triclosan release from coated polyglycolide threads.
Raül Zurita1, Jordi Puiggalí, Alfonso Rodríguez-Galán
1Departament d'Enginyeria Química, Universitat Politècnica de Catalunya, 08028 Barcelona, Spain.
Macromolecular Bioscience
|December 24, 2005
Summary
Researchers developed a novel suture coating using a specific copolymer blend. This optimized coating effectively incorporates and releases the antimicrobial agent triclosan, showing promise for enhanced surgical applications.
Area of Science:
- Polymer Chemistry
- Biomaterials Science
- Drug Delivery Systems
Background:
- Suture coatings require specific properties like amorphous character, low glass transition temperature, controlled degradation, and hydrophobicity for optimal antimicrobial agent delivery.
- Incorporating agents like triclosan into coatings can enhance antimicrobial properties of surgical sutures.
Purpose of the Study:
- To synthesize and characterize a copolymer for suture coating applications.
- To evaluate the incorporation and release kinetics of triclosan from the developed suture coating.
- To determine the optimal copolymer composition for desired coating properties.
Main Methods:
- Copolymerization of lactide, epsilon-caprolactone, and trimethylene carbonate.
- Characterization of copolymer properties (amorphous nature, glass transition temperature, degradation susceptibility, hydrophobicity).
- High-performance liquid chromatography (HPLC) to study triclosan release from coated polyglycolide threads under various conditions.
Main Results:
- A copolymer composition of 10:60:30 (lactide:epsilon-caprolactone:trimethylene carbonate) yielded the desired properties for a suture coating.
- Triclosan release was rapid in Dulbecco's medium and reached equilibrium in Sörensen medium.
- Factors influencing triclosan incorporation, including temperature and initial concentration, were evaluated.
Conclusions:
- The 10:60:30 copolymer composition is suitable for developing antimicrobial suture coatings.
- The release profile of triclosan is dependent on the surrounding medium's hydrophilicity.
- This study provides insights into designing effective antimicrobial suture coatings with controlled drug release.