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Migraine with aura is a risk factor for unprovoked seizures in children
Petur Ludvigsson1, Dale Hesdorffer, Elias Olafsson
1Department of Pediatrics, Landspitalinn University Hospital, Reykjavik, Iceland.
Objective:
Migraine is associated with epilepsy, but the time order and nature of the relationship are unclear. We conducted a population based case control study to clarify the time order to determine whether migraine is a risk factor for epilepsy.
Methods:
Migraine symptoms were evaluated in a population-based case-control study of all incident epilepsy in Icelandic children and in matched controls (next two same sex births in the country).
Results:
Migraine was associated with a fourfold increased risk for developing epilepsy, an association explained by migraine with aura (odds ratio, 8.1; 95% confidence interval, 2.7-24.3). Migraine without aura did not increase risk for epilepsy.
Interpretation:
Children with migraine with aura have a substantial increased risk to develop subsequent epilepsy. This finding is consistent with the hypothesis that migraine with aura and migraine without aura may be different disorders.
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