Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A cross-sectional survey on pharmacists' protection against hazardous drugs in China based on USP <800>, NIOSH and ISOPP standards: Comparative analysis and improvement suggestions.

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners·2026

Same author

Therapeutic Efficacy of Dual-Targeting Nanoparticles with Low Immunogenicity in the Treatment of Rheumatoid Arthritis.

Journal of functional biomaterials·2026

Same author

Exercise-induced muscle injury in Duchenne muscular dystrophy: impaired mitophagy and altered PINK1-PARKIN pathway in mdx mice.

Brain & development·2026

Same author

Association between estimated glucose disposal rate and sarcopenia in U.S. adults: a cross-sectional study based on NHANES 2011-2018.

Diabetology & metabolic syndrome·2026

Same author

Self-assembled EDIII/NS1 nanoparticle vaccines elicit protective immune responses against Japanese encephalitis virus.

Antiviral research·2026

Same author

Non-leukemic myeloid sarcomas involving only the central nervous system: a case report and literature review.

Frontiers in oncology·2026

Same journal

From Cation Solvation to Anion Coordination: Lewis-Acidic Boranes Enable Halide Salt Electrolytes.

The journal of physical chemistry. B·2026

Same journal

In Vitro-Prepared A30P Alpha-Synuclein Fibrils Adopt the Conserved and Disease-Relevant Greek Key Fold.

The journal of physical chemistry. B·2026

Same journal

Metastructure Analysis of Self-Assembled Nanocubes with Different Equatorial Methyl Groups Based on Molecular Dynamics Simulations.

The journal of physical chemistry. B·2026

Same journal

A Cocoordinated <sup>1</sup>H Internal Reference Quantifies Proton-Exchange Bias in Coordinated-Water Diffusion.

The journal of physical chemistry. B·2026

Same journal

Unveiling Electrolyte-Dependent Coordination Site Dynamics for Redox Mediator Design in Lithium-O<sub>2</sub> Batteries: Exchange vs Rearrangement.

The journal of physical chemistry. B·2026

Same journal

The Role of Functional Groups in Substituted Benzoic Acids Used as Dopants in Liquid Crystal Mixtures on the Nematic-Isotropic Transitions.

The journal of physical chemistry. B·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jan 4, 2026

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

Self-folding of three-dimensional hydrogel microstructures.

Jingjiao Guan¹, Hongyan He, Derek J Hansford

¹Biomedical Engineering Center and Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210, USA.

The Journal of Physical Chemistry. B

|December 27, 2005

Summary

This summary is machine-generated.

Researchers created 3D hydrogel microstructures by combining soft lithography and self-folding. This method uses differential swelling in bilayer structures to form complex shapes, controllable by polymer composition.

More Related Videos

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Published on: January 11, 2016

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

Related Experiment Videos

Last Updated: Jan 4, 2026

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

An Additive Manufacturing Technique for the Facile and Rapid Fabrication of Hydrogel-based Micromachines with Magnetically Responsive Components

Published on: July 18, 2018

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Construction of Modular Hydrogel Sheets for Micropatterned Macro-scaled 3D Cellular Architecture

Published on: January 11, 2016

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Printing Thermoresponsive Reverse Molds for the Creation of Patterned Two-component Hydrogels for 3D Cell Culture

Published on: July 10, 2013

Area of Science:

Materials Science
Biomaterials Engineering
Microfabrication

Background:

Hydrogel microstructures are crucial for various applications, including drug delivery and tissue engineering.
Existing fabrication methods often lack control over complex three-dimensional (3D) structure formation.

Purpose of the Study:

To develop a novel method for fabricating 3D particulate-like hydrogel microstructures.
To demonstrate control over the curvature and complexity of these 3D structures.
To provide a predictive model for the self-folding behavior.

Main Methods:

Fabrication of bilayer hydrogel structures using soft lithography (solvent casting and photocuring).
Induction of self-folding into 3D structures via volume expansion upon contact with water due to differential swelling.
Control of curvature by adjusting polymer composition of the swelling layer.
Development of a semiempirical mathematical model to predict self-folding.

Main Results:

Successfully fabricated 3D particulate-like hydrogel microstructures.
Demonstrated controllable self-folding behavior by adjusting polymer composition.
Showcased the ability to create complex 3D shapes from designed 2D bilayer precursors.
Validated the predictive capability of the mathematical model.

Conclusions:

The combination of soft lithography and volume expansion-induced self-folding offers a versatile platform for creating complex 3D hydrogel microstructures.
This technique allows for precise control over 3D morphology, opening avenues for advanced biomaterial designs.
The developed model aids in the rational design of 2D precursors for predictable 3D structure formation.