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Clopidogrel use in coronary artery disease

Aaron L Baggish1, Marc S Sabatine

  • 1Department of Cardiology, Massachusetts General Hospital, Boston, MA, USA. abaggish@partners.org

Expert Review of Cardiovascular Therapy
|December 27, 2005
PubMed

Insights

Clopidogrel, an adenosine diphosphate receptor antagonist, effectively inhibits platelet activation. Its benefits are well-established for patients with stable coronary artery disease and acute coronary syndromes.

Area of Science:

  • Cardiology
  • Pharmacology
  • Hematology

Background:

  • Platelet activation is key in acute coronary syndromes.
  • Clopidogrel is an oral thienopyridine and adenosine diphosphate receptor antagonist.
  • It inhibits platelet activation, crucial for cardiovascular events.

Purpose of the Study:

  • To review clopidogrel's pharmacology.
  • To highlight clopidogrel trial results in acute coronary syndromes.
  • To identify areas of uncertainty and future research directions.

Main Methods:

  • Review of clopidogrel pharmacology.
  • Analysis of clinical trial data in acute coronary syndromes.
  • Synthesis of existing literature on clopidogrel efficacy.

Main Results:

  • Clopidogrel benefits are established in stable coronary artery disease and acute coronary syndromes.
  • The drug's utility has been evaluated in numerous patient trials.
  • Evidence supports its role in preventing thrombotic events.

Conclusions:

  • Clopidogrel is a vital therapeutic agent for acute coronary syndromes.
  • Further research is needed to address remaining uncertainties.
  • Optimal use in various clinical settings continues to be explored.

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