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The new immunosuppression: intervention at the dendritic cell-T-cell interface

A M Paterson1, S F Yates, K F Nolan

  • 1Sir William Dunn School of Pathology, University of Oxford, South Parks Road, UK. alison.paterson@path.ox.ac.uk

Current Drug Targets. Immune, Endocrine and Metabolic Disorders
|December 27, 2005
PubMed

Dendritic cells (DCs) play an important role in initiating and directing T-cells towards immunity or tolerance. An important aim of emerging immunosuppressive strategies is to ensure that antigen is perceived in a 'tolerogenic context'. This would have obvious benefit in minimising the need for long-term drug maintenance in organ transplantation, hypersensitivity and autoimmune diseases. Here we review the biology of the interplay between the DC and T-cell, with a specific focus on therapeutic drugs targeting molecules that effect their interaction and function.

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