Incidence and risk factors for medical complications after carotid artery stenting
Klaus Gröschel1, Ulrike Ernemann, Axel Riecker
1Department of Neurology, University of Tübingen, Tübingen, Germany.
Insights
Medical complications after carotid angioplasty and stenting (CAS) occur in 15% of patients, with older age and symptomatic stenosis being key risk factors. Close monitoring of these patients is recommended to manage potential adverse events.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Vascular Surgery
Background:
- Carotid angioplasty and stenting (CAS) is an alternative to carotid endarterectomy for carotid artery stenosis.
- Limited data exists on the incidence of medical complications following CAS.
Purpose of the Study:
- To determine the frequency of medical complications after CAS.
- To identify clinical risk factors associated with medical complications post-CAS.
Main Methods:
- A cohort of 327 patients undergoing CAS for symptomatic or asymptomatic carotid artery stenosis were analyzed.
- Medical complications within 30 days of CAS were recorded.
- Logistic regression was used to identify predictors of medical complications.
Main Results:
- 15% of patients (51/327) experienced 62 medical complications.
- Common complications included hypotension (4.9%), chest infections (3.1%), and confusion (2.7%).
- Advanced age (OR 1.1) and symptomatic carotid stenosis (OR 2.1) independently predicted medical complications.
Conclusions:
- The overall incidence of medical complications after CAS may be higher than anticipated.
- Older patients and those with symptomatic stenosis are at increased risk.
- Close monitoring of high-risk subgroups is advised.
Objective:
Carotid angioplasty and stenting (CAS) is being evaluated as an alternative to carotid endarterectomy for the treatment of carotid artery stenosis; however, to date little is known about the incidence of medical complications after CAS. The goal of this study was to determine the frequency of, and to identify potential clinical risk factors for, the development of medical complications after CAS.
Methods:
Medical complications that occurred < or = 30 days after CAS in 327 consecutive patients (241 men, 86 women; mean age, 69 +/- 9 years; range, 45 to 90 years) treated for symptomatic (n = 182, 56%) or asymptomatic (n = 145, 44%) carotid artery stenosis were recorded. The effect of clinical characteristics on the subsequent development of medical complications was analyzed by logistic regression.
Results:
Fifty-one patients (15%) had 62 medical complications: 3 (0.9%) myocardial infarctions, 3 (0.9%) cardiac arrhythmias, 4 (1.2%) episodes of angina pectoris, 3 (0.9%) episodes of symptomatic hypertension, 16 (4.9%) episodes of symptomatic hypotension, 10 (3.1%) chest infections, 9 (2.7%) had periods of confusion, 5 (1.5%) had urinary retention, and 9 (2.7%) urinary tract infections. One chest infection was fatal and 16 complications prolonged the intensive care unit monitoring period > 24 hours. Advanced age (odds ratio [OR], 1.1; 95% confidence interval [CI], 1.05 to 1.14) and a symptomatic carotid stenosis (OR, 2.1; 95% CI, 1.07 to 4.1) independently predicted the occurrence of medical complications.
Conclusion:
Although life-threatening or fatal non-neurologic events were uncommon in this series, the overall incidence of medical complications after CAS might be higher than currently anticipated. Older and symptomatic patients are at the highest risk, and these subgroups should be monitored closely.
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