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Published on: May 23, 2025
Treatment of corticosteroid dependent optic neuropathy with intravenous immunoglobulin
Daryl Kurz1, Robert A Egan, James T Rosenbaum
1The Retina Group, Columbus, Ohio, USA.
Purpose:
To report a patient with corticosteroid dependent optic neuropathy treated with intravenous immunoglobulin (IVIg).
Design:
Interventional case report.
Methods:
Records review.
Results:
A 25-year-old woman developed bilateral vision loss with pain on eye movement in association with disk edema, dilated retinal veins, and hemorrhage. The vision improved markedly with prednisone, but she required a minimum of 20 mg/d despite concomitant therapy with methotrexate, cyclosporine, and/or mycophenolate mofetil. IVIg, 0.5 g/kg/d for 3 days each month with subsequent reduction in frequency, allowed discontinuation of all immunosuppression.
Conclusions:
Corticosteroid dependent optic neuropathy was successfully treated with IVIg.
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