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Updated: Aug 14, 2026
08:57
Pulsed Wave Doppler Assessment of Diastolic Dysfunction in the ZSF-1 Rat Model of Pulmonary Hypertension Due to Left Heart Disease
Published on: May 22, 2026
Isovolumic but not ejection phase Doppler tissue indices detect left ventricular dysfunction caused by coronary
Mikiko Shimizu1, Masaki Nii, Igor E Konstantinov
1Division of Cardiology, Hospital for Sick Children, Toronto, Ontario, Canada.
Summary
Isovolumic acceleration (IVA) effectively detects left ventricular dysfunction caused by coronary constriction. This tissue Doppler echocardiography index shows promise as a clinical tool for diagnosing ischemia.
Area of Science:
- Cardiology
- Echocardiography
- Physiology
Background:
- Isovolumic acceleration (IVA) via tissue Doppler echocardiography (TDE) assesses systolic ventricular function.
- IVA is relatively load-independent and reflects the force-frequency relationship.
Purpose of the Study:
- To evaluate IVA's ability to detect global left ventricular (LV) dysfunction induced by coronary constriction.
Main Methods:
- Open-chest pigs underwent TDE and invasive hemodynamic measurements.
- Left anterior descending coronary artery (LAD) constriction was induced using a pneumatic cuff.
- Measurements were taken at baseline and after LAD blood flow reduction by 50%.
Main Results:
- LAD constriction significantly decreased LV pressure and maximum dP/dt.
- IVA and isovolumic velocity at the LV free wall were significantly reduced post-constriction.
- IVA and isovolumic velocity correlated with dP/dt.
Conclusions:
- IVA effectively detects changes in global LV systolic function during LAD constriction.
- IVA may serve as a valuable clinical tool for diagnosing myocardial ischemia.
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