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Smoking habits in psoriasis: a case control study.

C M Mills¹, E D Srivastava, I M Harvey

¹Department of Gastroenterology, University Hospital of Wales, Cardiff, U.K.

The British Journal of Dermatology

|July 1, 1992

Summary

Current smokers have a significantly higher risk of developing psoriasis. Smoking more than 20 cigarettes daily further elevates this risk, suggesting smoking is a key factor in psoriasis development.

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Area of Science:

Dermatology
Epidemiology

Background:

Psoriasis is a common chronic skin condition.
The role of smoking in psoriasis etiology is under investigation.

Purpose of the Study:

To investigate the association between smoking habits and the risk of developing psoriasis.
To explore dose-response relationships and specific disease distributions.

Main Methods:

A case-control study involving 108 patients with psoriasis and matched community controls.
Analysis of current smoking status, smoking history before disease onset, and smoking quantity.

Main Results:

Significant association found between psoriasis and current smoking (OR=2.7) and prior smoking (OR=3.75).
A dose-response relationship was observed, with heavy smokers (>20 cigarettes/day) showing a markedly elevated risk (OR=5.3).

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Association persisted even in patients without palmoplantar psoriasis.

Conclusions:

Smoking is significantly associated with an increased risk of developing psoriasis.
Evidence suggests a dose-dependent relationship between smoking intensity and psoriasis risk.
Smoking may be a contributing factor to the etiology of psoriasis.