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Synthesis and in vitro evaluation of pseudosaccharinamine derivatives as potential elastase inhibitors

Haridas Rode1, Stefanie Koerbe, Anita Besch

  • 1Department of Pharmaceutical/Medicinal Chemistry, Institute of Pharmacy, Ernst-Moritz-Arndt-University, Friedrich-Ludwig-Jahn-Str. 17, D-17489 Greifswald, Germany.

Bioorganic & Medicinal Chemistry
|December 27, 2005
PubMed

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Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.