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Modeling and Evaluation of Murine Diabetic Cardiomyopathy Model
Published on: November 29, 2024
Flow mediated dilatation and cardiac function in type 1 diabetes mellitus
Bharati Shivalkar1, Dominique Dhondt, Inge Goovaerts
1Department of Cardiology, University Hospital Antwerp, Edegem, Belgium. bharati.shivalkar@skynet.be
The American Journal of Cardiology
|December 27, 2005
Summary
Subclinical cardiovascular issues and cardiac dysfunction increase with longer type 1 diabetes duration. Reduced flow-mediated dilation (FMD) is linked to abnormal heart function in these patients.
Area of Science:
- Cardiology
- Endocrinology
- Diabetology
Background:
- Type 1 diabetes mellitus (DM) poses risks for cardiovascular disease.
- Subclinical cardiovascular abnormalities in type 1 DM are not well-documented.
- Early detection of cardiac dysfunction is crucial for managing type 1 DM.
Purpose of the Study:
- To investigate subclinical cardiovascular risk markers and cardiac dysfunction in type 1 DM patients.
- To assess the impact of diabetes duration on these markers.
- To identify predictors of cardiac dysfunction in type 1 DM.
Main Methods:
- 100 type 1 DM patients and 75 controls underwent echocardiography, pulse-wave tissue Doppler (tD) mapping, flow-mediated dilation (FMD) of the brachial artery, and carotid intima-media thickness (IMT) measurement.
- Diastolic function was assessed using the Em/Am ratio.
- Laboratory analyses and stepwise regression were performed.
Main Results:
- Type 1 DM patients showed reduced FMD and increased IMT compared to controls.
- Abnormalities in regional diastolic and systolic function were detected early in the disease.
- Reduced FMD was the strongest predictor of abnormal segmental cardiac function.
Conclusions:
- Subclinical cardiac dysfunction and cardiovascular risk increase with type 1 DM duration.
- Flow-mediated dilation is significantly associated with abnormal segmental cardiac function in type 1 DM.
- These findings highlight the importance of monitoring cardiovascular health in type 1 DM patients.
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