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Updated: Aug 14, 2026

A Murine Model of Muscle Training by Neuromuscular Electrical Stimulation
Published on: May 9, 2012
Emerin increase in regenerating muscle fibers
S Squarzoni1, P Sabatelli, C Capanni
1ITOI-CNR, Unit of Bologna c/o Istituti Ortopedici Rizzoli, Bologna, Italy. squarzoni@area.bo.cnr.it
Abstract:
The fate of emerin during skeletal muscle regeneration was investigated in an animal model by means of crush injury. Immunofluorescence, immunoblotting and mRNA analysis demonstrated that emerin level is increased in regenerating rat muscle fibers with respect to normal mature myofibers. This finding suggests an involvement of emerin during the muscle fiber regeneration process, in analogy with its reported involvement in muscle cell differentiation in vitro. The impairment of skeletal muscle physiological regeneration or reorganization could be a possible pathogenetic mechanism for Emery Dreifuss muscular dystrophy.
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