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Cord insulin and C-peptide--distribution in an unselected population
K P Stanley1, R B Fraser, M Milner
1University Department of Obstetrics and Gynaecology, Northern General Hospital, Sheffield, UK.
Objective:
To assess the distribution of cord blood insulin in an unselected population, and examine its relation to birthweight centiles.
Setting:
District General Hospital in Nottinghamshire.
Subjects:
209 unselected singleton births.
Mean Outcome Measure:
Cord blood insulin; cord blood C-peptide; birthweight centiles.
Results:
Hyperinsulinaemic babies (greater than 97th centile for cord insulin) were found at all birthweight centiles. 15% of high birthweight babies were hyperinsulinaemic. For low birthweight babies, the distribution of cord insulin/C-peptide was skewed indicating a high number of low values. Hypoinsulinaemic babies were present up to the 50th centile for birthweight.
Conclusions:
Abnormalities of fetal insulinisation may be found in babies of all birthweights.