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Neurological recovery after decompressive craniectomy for massive ischemic stroke
Arnold Cheung1, Christopher K Telaghani, Jianli Wang
1Department of Neurological Surgery, Pennsylvania State University College of Medicine, M. S. Hershey Medical Center, Hershey, PA 17033, USA.
Insights
Decompressive craniectomy aids functional recovery after massive stroke. Brain imaging reveals neural activity in both hemispheres, suggesting decompression alone may be preferable to infarct resection.
Area of Science:
- Neuroscience
- Neurosurgery
- Radiology
Background:
- Decompressive craniectomy is effective for reducing mortality in massive hemispheric cerebral infarction.
- The patterns of functional recovery post-decompressive craniectomy remain unclear.
- The appropriateness of infarct resection (strokectomy) versus decompression alone is debated.
Observation:
- Functional magnetic resonance imaging (f-MRI) assessed functional recovery in three patients 13-26 months after decompressive craniectomy for massive ischemic stroke.
- Brain activation was studied during hand-gripping and foot-movement tasks.
- Clinical follow-up was integrated with f-MRI results.
Findings:
- f-MRI showed sensorimotor cortex activation in the contralateral hemisphere.
- Lesser activation was observed in the infarcted hemisphere, with peri-infarct activity in two patients.
- No activation occurred within the initial infarction area; all patients showed neurological improvement.
Implications:
- Patients can achieve functional recovery through activation in both hemispheres after decompressive craniectomy.
- Peri-infarct recovery suggests decompressive craniectomy alone may be superior to strokectomy.
- This supports decompression as a potentially safer approach, minimizing damage to adjacent brain tissue.
Introduction:
Decompressive craniectomy has demonstrated efficacy in reducing morbidity and mortality in critically ill patients with massive hemispheric cerebral infarction. However, little is known about the patterns of functional recovery that exist in patients after decompressive craniectomy, and controversy still exists as to whether craniotomy and infarct resection ("strokectomy") are appropriate alternatives to decompression alone. We therefore used functional magnetic resonance imaging (f-MRI) to assess the extent and location of functional recovery in patients after decompressive craniectomy for massive ischemic stroke.
Methods:
f-MRI was obtained in three patients with massive nondominant cerebral infarction who had undergone decompressive craniectomy for severe cerebral edema 13 to 26 months previously. Brain activation was triggered by hand-gripping or foot- movement tasks. Imaging results were combined with periodic clinical follow-up to determine the extent of neurological recovery.
Results:
Activation of the contralateral hemisphere was seen in the sensorimotor cortex, premotor, and supplementary motor areas. Lesser activation patterns were seen in equivalent regions of the infarcted hemisphere. Peri-infarct activation foci were seen in two of the three patients, but no activation occurred within the area of infarction as defined by the initial stroke seen on diffusion-weighted MRI. All three patients demonstrated some corresponding neurological improvement.
Conclusion:
After massive hemispheric cerebral infarction requiring decompressive craniectomy, patients may experience functional recovery as a result of activation in both the infarcted and contralateral hemispheres. The evidence of functional recovery in peri-infarct regions suggests that decompression alone may be preferable to strokectomy where the risk of damage to adjacent nonischemic brain may be greater.
