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Updated: Aug 14, 2026
An Adipocyte Cell Culture Model to Study the Impact of Protein and Micro-RNA Modulation on Adipocyte Function
Published on: May 4, 2021
Inhibition of preadipocyte differentiation by germacranolides from Calea urticifolia in 3T3-L1 cells
Nobuyasu Matsuura1, Masashi Yamada, Hiroto Suzuki
1Department of Life Science, Faculty of Science, Okayama University of Science, Japan. nobuyasu@dis.ous.ac.jp
Abstract:
The effects of germacranolides isolated from Calea urticifolia on adipocytic differentiation of 3T3-L1 cells were examined. These germacranolides inhibited adipogenesis at a concentration of 1.25-5 microM. But no inhibitory activity against cell proliferation and no nonspecific binding activity to protein were observed. These results indicate that these germacranolides are the specific inhibitors of preadipocyte differentiation.
