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Updated: Aug 14, 2026
In Vivo Imaging of Dauer-specific Neuronal Remodeling in C. elegans
Published on: September 4, 2014
Lifespan extending activity of substances secreted by the nematode Caenorhabditis elegans that include the
Tsuyoshi Kawano1, Naoya Kataoka, Sunao Abe
1Department of Biological and Environmental Chemistry, Faculty of Agriculture, Tottori University, Japan. kawano@muses.tottori-u.ac.jp
Abstract:
The nematode Caenorhabditis elegans yields a substance(s) inducing the larval diapause, called dauer-inducing pheromone. We discovered that the crude pheromone extract extends the adult lifespan in the animal. This extension does not occur in the mutant animal, in which expansion of the lifespan caused by other mutations reducing insulin signaling is suppressed. This is the first description concerning the relevancy of the pheromone to the longevity in the animal.
