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Normal postprandial lipemia in men with low plasma HDL concentrations
1Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas 75235.
Arteriosclerosis and Thrombosis : a Journal of Vascular Biology
|August 1, 1992
Summary
Low high density lipoprotein (HDL) cholesterol in men with normal triglycerides is not caused by impaired fat metabolism after meals. Other factors likely explain low HDL cholesterol levels.
Area of Science:
- Cardiovascular Science
- Lipid Metabolism
- Nutritional Science
Background:
- Low high density lipoprotein (HDL) cholesterol is a risk factor for cardiovascular disease.
- The relationship between postprandial lipemia and HDL cholesterol levels requires further investigation.
Purpose of the Study:
- To investigate the association between postprandial lipemia and high density lipoprotein (HDL) cholesterol concentrations in men.
- To determine if impaired chylomicron remnant metabolism contributes to low HDL cholesterol.
Main Methods:
- Measured plasma triglyceride and retinyl palmitate responses to fat meals in three groups of men: low HDL, normal HDL, and hypertriglyceridemic.
- Compared postprandial lipemia and chylomicron remnant metabolism across groups.
Main Results:
- Postprandial lipemia was significantly higher in hypertriglyceridemic men compared to normolipidemic groups.
- Men with low HDL cholesterol and normal triglycerides showed similar postprandial lipemia and chylomicron remnant metabolism as men with normal HDL.
- These findings indicate that exaggerated postprandial lipemia is not a common cause of low HDL cholesterol in men with normal triglyceride levels.
Conclusions:
- Low HDL cholesterol concentrations in normotriglyceridemic men are likely due to factors other than excessive postprandial lipemia.
- Defects in chylomicron-triglyceride clearance do not appear to be a primary driver of low HDL cholesterol in this population.