Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Diffuse muscular calcification with subcutaneous cysts].

Guang-li Shen1, Wei Zhang, Yi Li

  • 1Department of Neurology,Peking University First Hospital,Beijing 100034,China.

Beijing Da Xue Xue Bao. Yi Xue Ban = Journal of Peking University. Health Sciences
|December 27, 2005
PubMed
Summary

This case study presents a rare instance of diffuse muscular calcification in a young girl, mimicking myositis ossificans progressiva. The findings suggest a potential new congenital calcium metabolic disease with unique microvascular changes.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Transcriptome sequencing provides novel insights into larval development and sexual dimorphism in the firefly Aquatica leii (Coleoptera: Lampyridae).

Genomics·2026
Same author

Physiological and Proteomic Insights into Melatonin-Mediated Regulation of Copper Toxicity in the Crayfish <i>Procambarus clarkii</i>.

International journal of molecular sciences·2026
Same author

Multi-time point transcriptomics and metabolomics reveals toxic responses of imidacloprid exposure in Aquatica leii (Coleoptera: Lampyridae).

Pesticide biochemistry and physiology·2026
Same author

Fast Dissolving Resveratrol-Polyvinylpyrrolidone Nanofibrous Films Fabricated in Bulk Using a Special Hole Electrospinning Technique.

Polymers·2026
Same author

Aberrant SOD1 aggregates in skeletal muscle target fibers in amyotrophic lateral sclerosis.

Acta neuropathologica·2026
Same author

The clinical, serological and myopathological features of a cohort of Chinese patients with inclusion body myositis: a single center analysis.

Frontiers in immunology·2026

Area of Science:

  • Pathology
  • Genetics
  • Metabolic Disorders

Background:

  • Diffuse muscular calcification is a rare myopathological change linked to abnormal calcium metabolism.
  • It is primarily observed in dermatomyositis and myositis ossificans progressiva.

Observation:

  • A 15-year-old girl presented with subcutaneous cysts, fever, myalgia, and diffuse muscular calcification.
  • Clinical presentation mimicked myositis ossificans progressiva, with nodules rupturing and releasing chalky material.
  • Diagnostic tests including ESR, ENA, RF, CRP, PTH, CK, and EMG were within normal limits; X-rays confirmed diffuse calcification.

Findings:

  • Muscle biopsy revealed perivascular inflammatory cell infiltration, perifascicular muscle fiber atrophy, and degeneration.
  • Numerous "red ragged fibers" (RRF) and succinate dehydrogenase (SDH) positive fibers were noted.

Related Experiment Videos

  • Electron microscopy identified tubular reticular inclusions within vascular endothelium.

    • Implications:

    • The case suggests a potential new type of congenital calcium metabolic disease due to systemic calcium metabolic abnormality.
    • Distinct clinical symptoms and calcification patterns differentiate it from dermatomyositis and myositis ossificans progressiva.
    • Microvascular changes are hypothesized to be the cause of muscle fiber lesions.