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Current pathological and clinical aspects of Buerger's disease in Japan

Masayoshi Kobayashi1, Naomichi Nishikimi, Kimihiro Komori

  • 1Division of Vascular Surgery, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. koba@med.nagoya-u.ac.jp

Annals of Vascular Surgery
|December 27, 2005
PubMed

Insights

Buerger's disease, a distinct vascular condition, remains controversial regarding its etiology and diagnosis. This review examines its epidemiology, pathology, and clinical aspects in Japan, discussing pathogenesis and treatments.

Area of Science:

  • Vascular Surgery
  • Clinical Pathology
  • Epidemiology

Background:

  • Buerger's disease, first described in 1908, is a recognized vascular disease with characteristic features.
  • Despite recognition, its diagnosis and etiology remain debated due to varying international criteria.
  • The incidence of Buerger's disease has declined in Japan, unlike arteriosclerosis obliterans.

Purpose of the Study:

  • To review the current epidemiological, pathological, and clinical status of Buerger's disease in Japan.
  • To discuss the pathogenesis, clinical presentation, and treatment options for Buerger's disease.

Main Methods:

  • Analysis of 222 patient files from a single department between 1980 and 2000.
  • Review of existing literature on Buerger's disease diagnosis, etiology, and treatment.

Main Results:

  • The study examines trends in Buerger's disease incidence and characteristics over a 20-year period.
  • Comparison with arteriosclerosis obliterans highlights the declining prevalence of Buerger's disease.
  • The review synthesizes current understanding of the disease's multifaceted aspects.

Conclusions:

  • Buerger's disease, though less common, requires continued investigation into its pathogenesis and optimal management.
  • Standardized diagnostic criteria are crucial for accurate identification and research.
  • Further research is needed to elucidate the unknown etiology and refine treatment strategies.

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