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Multi-chamber intracardiac thrombi associated with activated protein C resistance in a patient with dilated

Mucahit Yetim1, Ozcan Ozeke, Bulent Deveci

  • 1Department of Cardiology, Yuksek Ihtisas Hospital, Ankara, Turkey.

The International Journal of Cardiovascular Imaging
|December 27, 2005
PubMed

Insights

Activated protein C resistance combined with dilated cardiomyopathy increases thrombosis risk. This case highlights the need to screen young patients with cardiac thrombosis for coagulation disorders.

Area of Science:

  • Cardiology
  • Hematology
  • Genetics

Background:

  • Dilated cardiomyopathy is a heart muscle disease that can lead to heart failure.
  • Activated protein C resistance is an inherited condition that increases the risk of blood clots.
  • The combined effect of these conditions on thrombosis risk is not well understood.

Observation:

  • A case of an 18-year-old patient with dilated cardiomyopathy is presented.
  • The patient exhibited multi-chamber intracardiac thrombi on transthoracic echocardiography.
  • The patient was also found to have activated protein C resistance.

Findings:

  • This case suggests a potential association between activated protein C resistance and dilated cardiomyopathy.
  • The combination of these conditions may significantly elevate the risk of thrombosis, even in young individuals.
  • Intracardiac thrombi were observed in a patient with both conditions.

Implications:

  • Patients with cardiac thrombosis, particularly before adulthood, should be evaluated for underlying coagulation abnormalities.
  • Screening for activated protein C resistance may be warranted in young patients with unexplained cardiac thrombosis.
  • This case underscores the importance of a comprehensive diagnostic approach for patients with complex cardiovascular and hematological conditions.

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