Hypereosinophilic syndrome: case report

Area of Science:

• Hematology
• Gastroenterology
• Internal Medicine

Background:

• Hypereosinophilic syndrome (HES) is a group of disorders marked by high eosinophil counts and organ damage.
• Patients with HES may present with unexplained weight loss and liver abnormalities.

Purpose of the Study:

• To report a case of hypereosinophilic syndrome presenting with a liver lesion.
• To describe the diagnostic and treatment course for this patient.

Main Methods:

• Diagnosis of HES was confirmed via fine needle aspiration biopsy and bone marrow aspiration biopsy.
• Imaging studies including echocardiography, HRCT, CT, and ultrasonography were utilized.
• Treatment involved prednisolone, with gradual dose tapering.

Main Results:

• The patient presented with weight loss, eosinophilia, and a hypodense liver lesion.
• Initial imaging (echocardiography, HRCT) was normal.
• Post-treatment, CT scans were normal, but ultrasonography revealed a small residual lesion.
• Liver scintigraphy showed no activity in the lesion, suggesting a resolved process.

Conclusions:

• Hypereosinophilic syndrome can manifest with liver lesions that may resolve with treatment.
• A residual liver lesion after HES treatment, without activity on scintigraphy, may represent a prior infection.