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Updated: Aug 11, 2026

A Fish-feeding Laboratory Bioassay to Assess the Antipredatory Activity of Secondary Metabolites from the Tissues of Marine Organisms
Published on: January 11, 2015
Antimycobacterial scalarane-based sesterterpenes from the Red Sea sponge Hyrtios erecta
Diaa T A Youssef1, Lamiaa A Shaala, Samy Emara
1Department of Pharmacognosy and Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.
Abstract:
A new scalarane-type pentacyclic sesterterpene, sesterstatin 7 (1), was isolated from the Red Sea sponge Hyrtios erecta, together with 16-epi-scalarolbutenolide (2), 25-dehydroxy-12-epi-deacetylscalarin (3), 3-acetylsesterstatin 1 (4), and 21-acetoxydeoxyscalarin. The structure of 1 was elucidated by spectroscopic data interpretation. Sesterstatin 7 (1) showed 63% inhibition of Mycobacterium tuberculosis (H(37)Rv) at a concentration of 6.25 microg/mL. Compound 2 displayed moderate inhibitory activity, while 3 and 4 were weakly active against the same biological target.
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