Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Artificial O2 carriers: status in 2005.

Donat R Spahn1, Roman Kocian

  • 1Department of Anesthesiology, University Hospital Lausanne, CH - 1011 Lausanne, Switzerland. donat.spahn@chuv.hospvd.ch

Current Pharmaceutical Design
|December 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multimodal prehabilitation in patients with advanced ovarian cancer.

Gynecologic oncology·2026
Same author

Intraoperative Methadone Versus Epidural Analgesia for Perioperative Pain Management in Major Abdominal and Thoracic Surgery: A Retrospective Single-Center Study.

Journal of clinical medicine·2026
Same author

Ultrasound-guided core needle biopsy: evaluating adequacy, accuracy, and safety in gynecologic oncology.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society·2026
Same author

Generative AI in preanesthetic consultations: Effects on efficiency, documentation workload, quality, and physician-patient interaction: A simulation trial.

Journal of clinical anesthesia·2026
Same author

Pro-Con Debate: Formulaic Approach Using Fixed Ratios of Blood Components Versus Targeted Therapy Approach Guided By Viscoelastic Hemostatic Assays for Resuscitation in Traumatic Major Hemorrhage.

Anesthesia and analgesia·2026
Same author

Effectiveness of the Semi-Automated Post-ANaesthesia Discharge Assessment Tool: A Pre-Post Study Using Propensity Score Matching.

Nursing in critical care·2026

Artificial oxygen carriers, including hemoglobin-based and perfluorocarbon emulsions, are being developed as alternatives to donor blood transfusions. While advanced products are in clinical trials, none have yet received market approval.

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Toxicology

Background:

  • Donor blood is a limited resource with associated transfusion risks.
  • Artificial oxygen carriers are being developed to address these limitations.
  • Two main classes exist: hemoglobin-based oxygen carriers (HBOCs) and perfluorocarbon emulsions (PFCs).

Purpose of the Study:

  • To review the development, specifications, and clinical status of various artificial oxygen carriers.
  • To discuss the modifications, physiologic effects, efficacy, and side effects of HBOCs and PFCs.
  • To provide an overview of products in clinical trials and their market approval status.

Main Methods:

  • Review of existing literature and product information on artificial oxygen carriers.
  • Description of chemical modifications and formulations for hemoglobin-based oxygen carriers.

Related Experiment Videos

  • Explanation of perfluorocarbon emulsion preparation and properties.

    • Main Results:

    • Several HBOCs (e.g., HemAssist, HBOC-201, PolyHeme, Hemolink, MP4) and PFCs (e.g., Oxygent) have undergone development.
    • Modifications aim to stabilize hemoglobin, improve oxygen off-loading, and enhance circulation time.
    • Advanced products are in Phase III clinical trials, but market approval is pending.

    Conclusions:

    • Artificial oxygen carriers show promise as blood transfusion alternatives.
    • Further research and clinical trials are necessary to ensure safety and efficacy.
    • No artificial oxygen carrier has achieved market approval in major regions yet.