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A study of von Willebrand's disease in Jordan

A S Awidi1

  • 1Department of Medicine, Jordan University.

Annals of Hematology
|June 1, 1992
PubMed

Insights

This 9-year study in Jordan found von Willebrand

Area of Science:

  • Hematology
  • Genetics
  • Epidemiology

Background:

  • Von Willebrand's disease (VWD) is an inherited bleeding disorder.
  • Understanding VWD subtypes is crucial for diagnosis and management.
  • Data on VWD prevalence and subtypes in Middle Eastern populations, particularly Jordan, is limited.

Purpose of the Study:

  • To investigate the prevalence and subtypes of von Willebrand's disease in a Jordanian population.
  • To compare the VWD subtype distribution in Jordan with findings from European and American populations.

Main Methods:

  • A 9-year observational study involving 65 patients from 32 families.
  • Detailed clinical and laboratory evaluation of 61 patients.
  • Subtyping of VWD using von Willebrand factor multimer analysis.

Main Results:

  • Von Willebrand's disease was the second most common inherited bleeding disorder after hemophilia A in the study cohort.
  • Type I VWD and its variants were the most frequent, observed in 59% of patients.
  • Types II B (18%) and III (11.5%) showed a higher frequency compared to European and American populations, while Type II A was observed in 11.5%.

Conclusions:

  • Type I VWD is the most common subtype in Jordan.
  • The observed frequencies of Type II B and Type III VWD in Jordan are higher than those reported in Western populations.
  • The true prevalence of VWD in Jordan may be underestimated due to potential underdiagnosis of mild cases.

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