Related Experiment Video
Updated: Aug 3, 2026
Metabolic Glycoengineering of Sialic Acid Using N-acyl-modified Mannosamines
Published on: November 25, 2017
Relation of serum sialic acid with serum lipids in cardiac patients
Inayat-ur-Rahman1, S A Malik, Wilayat Ahmad Khan
1Institute of Paramedical Technologies, Gandhara Technologies, Gandhara University, Peshawar.
Insights
Elevated serum sialic acid levels are linked to coronary heart disease risk. This study found higher sialic acid and altered lipid profiles in cardiac patients, indicating its role in cardiovascular complications.
Area of Science:
- Biochemistry
- Cardiology
- Clinical Chemistry
Background:
- Elevated serum sialic acid is a known risk factor for coronary heart disease (CHD).
- Dyslipidemia often coexists with increased CHD risk.
- Understanding the relationship between sialic acid and lipid profiles in cardiac patients is crucial.
Purpose of the Study:
- To investigate serum sialic acid concentrations and lipid profiles in cardiac patients.
- To compare these levels with healthy control groups.
- To explore the implications of altered sialic acid levels in cardiovascular complications.
Main Methods:
- Serum sialic acid and lipid profiles (including HDL-C) were measured.
- Healthy subjects were divided into two groups (A1, A2).
- Cardiac patients were divided into male (Group B) and female (Group C) groups.
Main Results:
- A significant increase in serum sialic acid was observed in all cardiac patient groups compared to controls.
- Most lipid profile variables, except HDL-C, were significantly elevated in patients.
- HDL-C levels showed a significant decrease in cardiac patients.
Conclusions:
- Increased serum sialic acid levels are strongly associated with cardiac patients.
- The findings suggest a role for elevated sialic acid in the development of cardiovascular complications.
- Sialic acid may serve as a potential biomarker for cardiovascular risk assessment.
Abstract:
Elevated serum sialic acid concentration is a risk factor for coronary heart disease in general population along with dyslipidemia. Sialic acid and lipid profile was determined in healthy subjects (Group A1 and A2) and sixty cardiac patients, divided into two groups, group B comprising of thirty male patients and group C comprising of thirty female patients. A highly significant increase was observed in the level of sialic acid and different variables of lipid profile except HDL-C in all patients. HDL-C showed a significant decrease in patients. An increase in the level of sialic acid in cardiac patients showing the implications of raised level of sialic acid in the development of cardiovascular complications.
More Related Videos
Related Concept Videos
01:20Blood Studies for Cardiovascular System I: Cardiac Biomarkers
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...