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Updated: Aug 14, 2026

Assessment of Cerebral Lateralization in Children using Functional Transcranial Doppler Ultrasound (fTCD)
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Gender differences in handedness and speech lateralization related to early neurologic insults
John W Miller1, Suman Jayadev, Carl B Dodrill
1The Regional Epilepsy Center, Harborview Medical Center, Department of Neurology, University of Washington School of Medicine, Seattle, WA, USA. millerjw@u.washington.edu
Abstract:
Left-handedness is a normal variant but also may result from early-life brain insults. Speech typically resides in the left cerebral hemisphere in normal subjects. In 170 subjects with past brain injuries, bilateral or right hemisphere speech lateralization, determined by the intracarotid amobarbital procedure, was more frequent in females (19 vs 5, p = 0.003) as was left-handedness (26 vs 10, p = 0.004). This could be attributed to greater plasticity or functional symmetry in females.
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