Circulating leptin, zinc, and copper levels after extracorporeal circulation

Area of Science:

• Cardiology
• Endocrinology
• Metabolic research

Background:

• Leptin's role in acute stress from extracorporeal circulation is known.
• The relationship between leptin and zinc levels during this process was previously unexamined.

Purpose of the Study:

• To investigate circulating leptin, zinc, and copper levels before, during, and after extracorporeal circulation.
• To assess the effect of preoperative zinc administration on these levels.

Main Methods:

• Twenty patients undergoing elective coronary artery bypass grafting with extracorporeal circulation were studied.
• Blood samples were collected preoperatively (T0), post-operation (T1), and on the first postoperative day (T2).
• One group received preoperative oral zinc supplementation (50 mg/day for 5 days).

Main Results:

• Leptin levels significantly increased at T2 compared to T0 and T1 in both groups.
• Zinc levels decreased at T2 compared to T0 and T1 in both groups.
• Copper levels decreased at T1 and T2 compared to T0 in the control group, but increased at T2 compared to T1 in the zinc-supplemented group.

Conclusions:

• Circulating leptin increases post-extracorporeal circulation as an acute stress response.
• Zinc and copper levels decrease during this period.
• Preoperative zinc administration did not mitigate the observed increase in leptin levels.