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Updated: Aug 14, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
[The arthropathy of systemic sclerosis]
D Malesci1, G La Montagna, G Valentini
1Unità Operativa di Reumatologia, Seconda Università degli Studi di Napoli, Italia.
Joint involvement is common in systemic sclerosis (SSc), presenting as pain, stiffness, and tendon issues, primarily in hands and feet. Radiographic findings include calcinosis, bone resorption, and degenerative changes, posing diagnostic challenges.
Area of Science:
- Rheumatology
- Radiology
- Systemic autoimmune diseases
Background:
- Joint involvement is a frequent manifestation of systemic sclerosis (SSc), impacting a third of patients.
- Clinical findings include arthralgias, stiffness, and tendon sheath involvement, predominantly affecting the fingers, wrists, and ankles.
Purpose of the Study:
- To detail the spectrum of joint involvement and radiographic abnormalities in systemic sclerosis.
- To highlight diagnostic challenges and radiological patterns in SSc patients.
Main Methods:
- Review of clinical findings in SSc patients with joint involvement.
- Analysis of common radiographic abnormalities, including calcinosis, digital tuft resorptions, demineralization, joint space narrowing, and erosions.
- Classification of radiological patterns into inflammatory, degenerative, and fibrotic categories.
Main Results:
- Common radiographic findings in SSc include subcutaneous calcinosis and digital tuft resorptions, particularly in the hands.
- Juxtaarticular demineralization, joint space narrowing, and erosions can mimic other arthropathies like rheumatoid arthritis.
- A fibrotic pattern is more prevalent in the hands, while a degenerative pattern is more common in the feet.
Conclusions:
- Joint manifestations and radiographic changes are significant in systemic sclerosis, affecting all subsets.
- Radiographic findings can present diagnostic challenges, necessitating careful evaluation.
- Distinct radiological patterns exist, with variations observed between hands and feet.
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