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Trace elements and oxidative stress in chronic obstructive pulmonary disease
Birgul Isik1, Rana S Isik, Ali Ceylan
1Department of Biochemistry, Faculty of Medicine, Dicle University, Diyarbakir 21280, Turkey. birgul60@hotmail.com
Saudi Medical Journal
|December 29, 2005
Summary
Chronic obstructive pulmonary disease (COPD) is linked to oxidative stress, with higher copper and malondialdehyde (MDA) levels and lower paraoxonase (PON1) activity observed. These trace elements and oxidative markers play a role in COPD pathogenesis.
Area of Science:
- Biochemistry
- Pulmonology
- Environmental Health
Background:
- Trace elements influence antioxidative defense systems, impacting diseases like chronic obstructive pulmonary disease (COPD).
- Oxidative stress is implicated in the pathophysiology of COPD.
Purpose of the Study:
- To determine levels of trace elements involved in oxidative stress.
- To assess malondialdehyde (MDA) as an oxidative stress marker.
- To evaluate paraoxonase (PON1) activity as an antioxidant in COPD patients and smokers.
Main Methods:
- Study included 25 COPD patients and 20 healthy non-smokers.
- Participants were hospitalized patients at Dicle University, Turkey.
- Clinical condition of COPD patients was stable during the study period.
Main Results:
- COPD patients showed higher serum copper (Cu) and MDA concentrations compared to controls.
- Serum PON1 activity was lower in COPD patients.
- Significant differences in Cu, MDA, and PON1 were found between smokers and non-smokers within the COPD group, but not for Zn or Cu/Zn ratio.
Conclusions:
- Trace elements like copper, along with oxidants (MDA) and antioxidants (PON1), are implicated in oxidative stress and COPD.
- Findings suggest a role for these markers in the disease process.
- Further research into the specific roles of these elements in COPD is warranted.