Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Elastic image mapping for 4-D dose estimation in thoracic radiotherapy.

Thomas Guerrero¹, Geoffrey Zhang, William Segars

¹Department of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. tguerrero@mdanderson.org

Radiation Protection Dosimetry

|December 31, 2005

Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Evaluation of two treatment planning systems for single isocenter multiple metastases stereotactic radiosurgery treatment planning and delivery.

Medical dosimetry : official journal of the American Association of Medical Dosimetrists·2025

Same author

AAPM task group report 314: Fault recovery in external beam radiation therapy.

Medical physics·2024

Same author

Targeting MCL1-driven anti-apoptotic pathways to overcome hypomethylating agent resistance in <i>RAS</i> -mutated chronic myelomonocytic leukemia.

bioRxiv : the preprint server for biology·2023

Same author

The International Organization for Medical Physics - a driving force for the global development of medical physics.

Health and technology·2022

Same author

Robustness Assessment of Images From a 0.35T Scanner of an Integrated MRI-Linac: Characterization of Radiomics Features in Phantom and Patient Data.

Technology in cancer research & treatment·2022

Same author

Efficacy, safety, and dose-dependence of the analgesic effects of opioid therapy for people with osteoarthritis: systematic review and meta-analysis.

The Medical journal of Australia·2022

This study demonstrates path integration of four-dimensional (4-D) dose distributions in radiotherapy. Accurate 3-D dose estimates are achievable using elastic image registration, crucial for precise tumor coverage.

Area of Science:

Radiotherapy physics
Medical imaging
Computational anatomy

Background:

Four-dimensional (4-D) imaging captures anatomical motion during respiration.
Accurate dose calculation in 4-D requires accounting for tissue movement.
Tumor motion can compromise radiotherapy treatment efficacy.

Purpose of the Study:

To demonstrate the path integration of a four-dimensional (4-D) dose distribution onto three-dimensional (3-D) anatomy.
To evaluate the accuracy of 3-D dose estimation from 4-D data.

Main Methods:

A 4-D thoracic phantom with a lung tumor was created across eight respiratory phases.
Radiotherapy treatment planning was applied to all phases, generating a 4-D dose distribution.
Elastic image registration calculated vector displacements to integrate dose onto the end-expiration phase.

Related Experiment Videos

Main Results:

Path integration successfully calculated the tissue dose distribution.
Tumor motion led to asymmetric loss of tumor coverage, dependent on trajectory.
Comparison revealed discrepancies between planned and path-integrated dose distributions.

Conclusions:

Elastic image registration enables accurate path integration of 4-D datasets.
This method produces precise 3-D tissue dose estimates.
Accurate dose estimation is vital for optimizing radiotherapy for moving targets.