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Related Experiment Videos

CyBase: a database of cyclic protein sequence and structure.

Jason P Mulvenna1, Conan Wang, David J Craik

  • 1Institute for Molecular Bioscience, University of Queensland Brisbane, Queensland 4072, Australia.

Nucleic Acids Research
|December 31, 2005
PubMed
Summary

CyBase is a new database for cyclic proteins, including natural and synthetic types. It offers a central resource for cyclic protein biology and sequence searching.

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Structural Biology

Background:

  • Cyclic proteins exhibit unique structural and functional properties.
  • A centralized resource for managing and searching cyclic protein data is needed.

Purpose of the Study:

  • To introduce CyBase, a curated database for backbone-cyclized proteins.
  • To provide a comprehensive information source for cyclic protein biology.

Main Methods:

  • Curated data collection of naturally occurring and synthetic cyclic proteins.
  • Development of methods for managing and searching topologically circular sequences.

Main Results:

  • CyBase incorporates diverse cyclic protein types, including derivatives and permutants.

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  • The database addresses challenges in handling circular sequence data.

    • Conclusions:

    • CyBase serves as a valuable, freely accessible resource for researchers in cyclic protein biology.
    • Facilitates the study and discovery of cyclic protein structures and functions.