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The EROP-Moscow oligopeptide database
Alexander A Zamyatnin1, Alexander S Borchikov, Michail G Vladimirov
1A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, 33 Leninsky prosp., Moscow 119071, Russian Federation. aaz@inbi.ras.ru
Nucleic Acids Research
|December 31, 2005
Summary
A new database, EROP-Moscow, catalogs over 6000 natural oligopeptides and their properties. This resource aids in classifying novel oligopeptides and developing new peptide pharmaceuticals.
Area of Science:
- Biochemistry
- Bioinformatics
- Molecular Biology
Background:
- Natural oligopeptides regulate essential biological processes.
- Over 6000 oligopeptide structures from diverse organisms are known.
- Existing databases lack comprehensive data on these molecules.
Purpose of the Study:
- To create a centralized, accessible database of natural oligopeptides.
- To facilitate research on oligopeptide properties and functions.
- To support the classification of new oligopeptides and pharmaceutical development.
Main Methods:
- Compilation of physical, chemical, and biological properties of known oligopeptides.
- Development of an internet-accessible database, EROP-Moscow.
- Integration with existing biological databases like Swiss-Prot-TrEMBL and PubMed.
Main Results:
- The EROP-Moscow database is now available at http://erop.inbi.ras.ru.
- The database includes completely determined oligopeptide structures.
- It offers advanced search and statistical analysis functionalities.
Conclusions:
- EROP-Moscow provides a valuable resource for researchers studying natural oligopeptides.
- The database can accelerate the discovery and application of novel peptide pharmaceuticals.
- It serves as a key tool for classifying and understanding endogenous regulatory oligopeptides.