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The EROP-Moscow oligopeptide database.

Alexander A Zamyatnin¹, Alexander S Borchikov, Michail G Vladimirov

¹A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, 33 Leninsky prosp., Moscow 119071, Russian Federation. aaz@inbi.ras.ru

Nucleic Acids Research

|December 31, 2005

Summary

A new database, EROP-Moscow, catalogs over 6000 natural oligopeptides and their properties. This resource aids in classifying novel oligopeptides and developing new peptide pharmaceuticals.

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Area of Science:

Biochemistry
Bioinformatics
Molecular Biology

Background:

Natural oligopeptides regulate essential biological processes.
Over 6000 oligopeptide structures from diverse organisms are known.
Existing databases lack comprehensive data on these molecules.

Purpose of the Study:

To create a centralized, accessible database of natural oligopeptides.
To facilitate research on oligopeptide properties and functions.
To support the classification of new oligopeptides and pharmaceutical development.

Main Methods:

Compilation of physical, chemical, and biological properties of known oligopeptides.
Development of an internet-accessible database, EROP-Moscow.
Integration with existing biological databases like Swiss-Prot-TrEMBL and PubMed.

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Main Results:

The EROP-Moscow database is now available at http://erop.inbi.ras.ru.
The database includes completely determined oligopeptide structures.
It offers advanced search and statistical analysis functionalities.

Conclusions:

EROP-Moscow provides a valuable resource for researchers studying natural oligopeptides.
The database can accelerate the discovery and application of novel peptide pharmaceuticals.
It serves as a key tool for classifying and understanding endogenous regulatory oligopeptides.