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MEROPS: the peptidase database.

Neil D Rawlings1, Fraser R Morton, Alan J Barrett

  • 1The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK. ndr@sanger.ac.uk

Nucleic Acids Research
|December 31, 2005
PubMed
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The MEROPS database provides integrated information on peptidases (proteolytic enzymes) and their inhibitors. It features hierarchical classification, detailed annotations, and enhanced search functionalities for biological and medical research.

Area of Science:

  • Biochemistry
  • Proteomics
  • Bioinformatics

Background:

  • Peptidases (proteolytic enzymes) and their inhibitors are crucial in biology, medicine, and biotechnology.
  • Existing resources lack comprehensive, integrated information on these protein families.

Purpose of the Study:

  • To present the MEROPS database as an integrated resource for peptidase and inhibitor information.
  • To enhance the database with new features for improved usability and data discovery.

Main Methods:

  • Hierarchical classification of homologous proteins into families and clans.
  • Addition of concise text annotations for each peptidase family.
  • Implementation of features like active site residue highlighting, dynamic alignments/trees, and curated lists of active homologues.

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Main Results:

  • The MEROPS database offers a structured, hierarchical classification of peptidases and inhibitors.
  • New annotations, active site highlighting, and dynamic data visualizations enhance data accessibility.
  • Improved literature flagging and taxonomic displays aid researchers in identifying key information.

Conclusions:

  • The MEROPS database serves as a vital, integrated resource for researchers studying peptidases and inhibitors.
  • Enhanced features facilitate deeper understanding and discovery in proteomics and related fields.
  • The database supports advancements in biology, medicine, and biotechnology through accessible, curated protein information.