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Related Experiment Videos

The LIFEdb database in 2006.

Alexander Mehrle1, Heiko Rosenfelder, Ingo Schupp

  • 1Division Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, D-69120 Heidelberg, Germany. a.mehrle@dkfz.de

Nucleic Acids Research
|December 31, 2005
PubMed
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LIFEdb is a comprehensive database integrating functional genomics, gene expression, and protein data. It offers enhanced features for systematic gene and protein characterization, aiding biological research.

Area of Science:

  • Bioinformatics
  • Genomics
  • Proteomics

Background:

  • LIFEdb integrates functional genomics assay data, cDNA annotation, bioinformatics gene expression, and protein analysis.
  • Existing databases may lack integrated, user-friendly access to diverse biological datasets.

Purpose of the Study:

  • To present the updated features of the LIFEdb database.
  • To enhance researchers' capabilities in selecting and characterizing genes and proteins.
  • To provide a user-friendly web-based interface for accessing integrated biological data.

Main Methods:

  • Integration of large-scale functional genomics assays and manual cDNA annotation.
  • Inclusion of bioinformatics gene expression and protein analysis.
  • Development of an updated user interface with enhanced query capabilities and configurable output tables.

Related Experiment Videos

  • Integration of cell-based screening assay data and 'Electronic Northern' displays for relative gene expression using curated gene expression ontology information.

    • Main Results:

    • LIFEdb now features an updated interface with improved query functions.
    • Search results are configurable and downloadable in XML format.
    • New data from cell-based screening assays on protein-overexpression and cell proliferation are integrated.
    • Relative gene expression ('Electronic Northern') is displayed using curated gene expression ontology information.

    Conclusions:

    • The enhanced LIFEdb facilitates systematic selection and characterization of genes and proteins.
    • The user-friendly interface and integrated data empower biological research.
    • LIFEdb serves as a valuable resource for researchers in genomics, proteomics, and bioinformatics.