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Related Experiment Videos

The Mouse Genome Database (MGD): updates and enhancements.

Judith A Blake1, Janan T Eppig, Carol J Bult

  • 1The Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA. jblake@informatics.jax.org

Nucleic Acids Research
|December 31, 2005
PubMed
Summary

The Mouse Genome Database (MGD) provides integrated mouse genetic and genomic data to aid human biology research. Recent updates enhance its utility for identifying genes linked to complex phenotypes.

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Area of Science:

  • Genomics
  • Bioinformatics
  • Mouse Model Systems

Background:

  • The Mouse Genome Database (MGD) is crucial for integrating mouse genetic and genomic data.
  • Utilizing the mouse as a model organism aids in understanding human biology and disease.
  • Acquiring and integrating genetic, genomic, functional, and phenotypic data is a core MGD function.

Purpose of the Study:

  • To describe recent improvements and ongoing efforts of the Mouse Genome Database (MGD).
  • To highlight MGD's role in facilitating the use of mouse models for human biology and disease research.
  • To showcase MGD's capabilities in computational assessment for identifying candidate genes associated with complex phenotypes.

Main Methods:

  • Integration of genetic, genomic, functional, and phenotypic data for mouse genes.

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  • Collaboration within the bioinformatics community to establish data standards for resource exchange.
  • Incorporation of data from the biomedical literature.
  • Development of computational methods for assessing integrated biological data.

    • Main Results:

    • Enhanced phenotype resources and functional annotation capabilities.
    • Incorporation of an interactive genome browser for improved data visualization.
    • Facilitation of data exchange through defined referential and semantic standards.

    Conclusions:

    • MGD serves as a vital resource for mouse genetics and genomics research.
    • Recent enhancements improve MGD's utility for identifying disease-associated genes.
    • MGD supports the use of mouse models in biomedical research through integrated data and advanced tools.