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Plasma concentrations of adhesion molecules and chemokines in patients with essential hypertension

Andrzej Madej1, Bogusław Okopień, Jan Kowalski

  • 1Department of Clinical Pharmacology, Silesian University School of Medicine, Medyków 18, PL 40-752 Katowice, Poland. andrzejmadej@o2.pl

Pharmacological Reports : PR
|December 31, 2005
PubMed

Insights

Essential hypertension significantly elevates plasma levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) and Monocyte Chemoattractant Peptide 1 (MCP-1). These elevated inflammatory markers indicate increased endothelial injury in hypertensive patients.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Vascular Biology

Background:

  • Arterial hypertension leads to severe vascular complications including heart failure and stroke.
  • Inflammatory factors, adhesion molecules, and chemokines are implicated in vascular wall remodeling during hypertension.

Purpose of the Study:

  • To quantify plasma levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) and Monocyte Chemoattractant Peptide 1 (MCP-1) in patients with essential hypertension.
  • To compare these levels against those in healthy individuals.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) using R&D kits.
  • Plasma samples from essential hypertensive patients and healthy volunteers were analyzed.

Main Results:

  • Hypertensive patients exhibited significantly higher plasma sICAM-1 levels (279.2 +/- 8.8 ng/ml) compared to controls (224.4 +/- 1.8 ng/ml; p < 0.001).
  • MCP-1 levels were also significantly elevated in hypertensive patients (142.2 +/- 7 pg/ml) versus controls (95.4 +/- 36 pg/ml; p < 0.0001).

Conclusions:

  • Arterial hypertension, independent of other metabolic disorders, can increase sICAM-1 and MCP-1 expression.
  • Elevated sICAM-1 and MCP-1 contribute to the progression of endothelial injury in essential hypertension.

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