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Clinical features associated with nasal Staphylococcus aureus colonisation in Chinese children with

K L E Hon1, M C A Lam, T F Leung

  • 1Department of Paediatrics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, China. ehon@cuhk.edu.hk

Annals of the Academy of Medicine, Singapore
|December 31, 2005
PubMed

Insights

Staphylococcus aureus nasal colonization is common in children with atopic dermatitis (AD) and linked to more severe skin symptoms. Cloxacillin shows good sensitivity for treating S. aureus infections in these patients.

Area of Science:

  • Dermatology
  • Microbiology
  • Pediatrics

Background:

  • Staphylococcus aureus colonization and infection are frequently observed in children diagnosed with atopic dermatitis (AD).
  • Understanding the prevalence and clinical associations of S. aureus in pediatric AD is crucial for effective management.

Purpose of the Study:

  • To investigate the prevalence of S. aureus colonization in nasal and skin sites of Chinese children with moderate-to-severe atopic dermatitis.
  • To identify clinical correlations between S. aureus colonization and disease severity indicators.

Main Methods:

  • Bacteriologic culture of nasal and body swabs from Chinese children with moderate-to-severe AD (SCORAD score).
  • Swabs collected from nostrils, flexural sites, and lesional skin.
  • Analysis of S. aureus colonization rates and association with SCORAD scores, disease extent, oozing/crusting, and eosinophil counts.

Main Results:

  • S. aureus colonization was found in 22% of nasal swabs and 58% of flexural swabs.
  • Significant nasal S. aureus colonization correlated with higher SCORAD scores, more extensive disease, oozing/crusting, and elevated eosinophil counts.
  • Methicillin-sensitive S. aureus showed high sensitivity to cloxacillin and erythromycin; MRSA was rare.

Conclusions:

  • S. aureus is a primary pathogen in pediatric atopic dermatitis.
  • The anterior nares serve as a significant reservoir for S. aureus.
  • Cloxacillin and first-generation cephalosporins are effective treatment options for S. aureus in children with moderate-to-severe AD, given their favorable sensitivity profiles.
Abstract

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