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Related Experiment Videos

Plasma filtration.

H K Tan1, G Hart

  • 1Department of Renal Medicine, Singapore General Hospital, Singapore, and University of Melbourne, Victoria, Australia. grmthk@sgh.com.sg

Annals of the Academy of Medicine, Singapore
|December 31, 2005
PubMed
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Therapeutic plasma exchange (TPE) removes disease mediators from blood, offering a potential treatment for various conditions. This review focuses on membrane plasma filtration techniques and their clinical applications.

Area of Science:

  • Nephrology
  • Hematology
  • Neurology
  • Endocrinology

Background:

  • Therapeutic plasma exchange (TPE) or plasmapheresis is a medical procedure that separates plasma from whole blood.
  • This process removes plasma-borne humoral disease mediators, potentially attenuating disease severity.
  • TPE is an adjunctive therapy for endocrinological, neurological, renal/rheumatological, and haematological disorders.

Purpose of the Study:

  • To review membrane plasma filtration (PF) as a method for therapeutic plasma exchange.
  • To discuss the application of PF using continuous renal replacement therapy (CRRT) or hemodialysis (HD) machines.
  • To examine clinical considerations such as timing and intensity of TPE therapy.

Main Methods:

  • Focus on membrane plasma filtration (PF) techniques for plasma separation.

Related Experiment Videos

  • Discussion of PF performed using continuous renal replacement therapy (CRRT) or hemodialysis (HD) machines.
  • Exploration of modified plasma filtration incorporating sorbent technology to eliminate the need for replacement fluids.

    • Main Results:

    • Membrane plasma filtration offers a method for TPE, removing disease mediators.
    • Sorbent technology integrated with plasma filtration can obviate the need for plasma volume replacement fluids.
    • The review examines critical clinical aspects including initiation timing and therapy intensity.

    Conclusions:

    • Membrane plasma filtration is a key method in therapeutic plasma exchange.
    • Sorbent technology enhances plasma filtration by removing the need for replacement fluids.
    • Optimal clinical strategies for TPE initiation and intensity require further examination.