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Updated: Aug 14, 2026

MRI-guided Focused Ultrasound Thalamotomy for Patients with Medically-refractory Essential Tremor
Published on: December 13, 2017
A single-blind, open-label trial of sodium oxybate for myoclonus and essential tremor
S J Frucht1, W C Houghton, Y Bordelon
1Columbia University Medical Center, New York, USA. sf216@columbia.edu
Abstract:
The authors performed an open-label, rater-blinded, add-on study of sodium oxybate in 20 patients with ethanol-responsive myoclonus or essential tremor. Blinded ratings of videotaped examinations showed improvements in myoclonus at rest, stimulus-sensitive myoclonus, action myoclonus, functional performance, and postural and kinetic tremor. Tolerability was acceptable, and more than half of the patients chose to continue treatment after the trial. Double-blind placebo-controlled studies in these disorders are warranted.
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