Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evidence for a pseudoautosomal locus for schizophrenia. I: A replication study using phenotype analysis.

P Gorwood1, M Leboyer, T d'Amato

  • 1Laboratoire de'anthropologie biologique, INSERM V ISS, Université Paris VII, France.

The British Journal of Psychiatry : the Journal of Mental Science
|July 1, 1992
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Validation of the French version of the self-evaluation of negative symptoms (SNS)].

L'Encephale·2017
Same author

Finite element model of a below-knee amputation: a feasibility study.

Computer methods in biomechanics and biomedical engineering·2017
Same author

[Association between the violence in the community and the aggressive behaviors of psychotics during their hospitalizations].

L'Encephale·2017
Same author

Investigation of reference levels and radiation dose associated with abdominal EVAR (endovascular aneurysm repair) procedures across several European Centres.

European radiology·2017
Same author

17q21.31 duplication causes prominent tau-related dementia with increased MAPT expression.

Molecular psychiatry·2016
Same author

Alzheimer disease: modeling an Aβ-centered biological network.

Molecular psychiatry·2016

Researchers found evidence supporting a schizophrenia gene locus in the pseudoautosomal region of sex chromosomes. This finding, observed in French families, suggests a genetic link on the X and Y chromosomes for schizophrenia susceptibility.

Area of Science:

  • Genetics
  • Psychiatry
  • Human genetics

Background:

  • Epidemiological data previously suggested a schizophrenia susceptibility locus within the pseudoautosomal region of the X and Y chromosomes.
  • This region, known as the pseudoautosomal region (PAR), undergoes recombination during meiosis and shares homology between the X and Y chromosomes.

Purpose of the Study:

  • To replicate the proposed genetic linkage of schizophrenia to the pseudoautosomal region.
  • To investigate the transmission patterns of schizophrenia within multiply affected families to test the pseudoautosomal hypothesis.

Main Methods:

  • Analysis of 38 French families multiply affected with schizophrenia.
  • Utilized sibship and pairwise analyses, including weighted-pair corrections.
  • Employed three distinct family classification systems to evaluate the data.

Related Experiment Videos

Main Results:

  • Observed a significant excess of same-sex pairs in paternally derived sibships.
  • This finding aligns with predictions derived from the pseudoautosomal hypothesis.
  • The results provide replication of the initial epidemiological suggestion.

Conclusions:

  • The study provides evidence supporting a schizophrenia susceptibility locus within the pseudoautosomal region of the sex chromosomes.
  • The excess of same-sex pairs in paternally inherited sibships reinforces the role of this chromosomal region in schizophrenia etiology.
  • Further research into the specific genes within the PAR is warranted to elucidate the genetic mechanisms underlying schizophrenia.