Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hadamard transform ion mobility spectrometry.

Brian H Clowers1, William F Siems, Herbert H Hill

  • 1Department of Chemistry, Washington State University, Pullman, Washington 99164, USA. bhclowers@yahoo.com

Analytical Chemistry
|December 31, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Digital Revitalization of a Legacy Linear Ion Trap System.

Analytical chemistry·2026
Same author

Accessing Higher Order Mathieu Space Stability Zones to Narrow Isolation Widths Using Digital Quadrupole Time-of-Flight Mass Spectrometry.

Journal of the American Society for Mass Spectrometry·2025
Same author

Phase Modulation to Increase Ion Throughput for Ion Mobility-Time-of-Flight Experiments.

Journal of the American Society for Mass Spectrometry·2025
Same author

A Hybrid Vacuum Flange RF Oscillator for Low-Cost Mass Spectrometry.

Journal of the American Society for Mass Spectrometry·2025
Same author

Efficient Coupling of Structures for Lossless Ion Manipulations with Ion Trap Mass Analyzers Using Phase Modulation.

Journal of the American Society for Mass Spectrometry·2025
Same author

Advancing Protein Analysis: A Low-Pressure Drift Tube Orbitrap Mass Spectrometer for Ultraviolet Photodissociation-Based Structural Characterization.

Analytical chemistry·2024

Hadamard transform (HT) ion mobility spectrometry (IMS) improves signal-to-noise ratio (SNR) by using a 50% duty cycle. This novel technique enhances data acquisition without compromising spectral resolution.

Area of Science:

  • Analytical Chemistry
  • Spectroscopy

Background:

  • Ion mobility spectrometry (IMS) typically averages multiple cycles for spectral acquisition.
  • Standard IMS methods suffer from low duty cycles (approx. 1%) to maximize resolution, leading to poor signal-to-noise ratio (SNR).
  • Spectral overlap can occur if ions from preceding cycles are not fully detected before the next cycle begins.

Purpose of the Study:

  • To introduce and evaluate the application of Hadamard transform (HT) to ion mobility spectrometry (IMS) as an alternative data acquisition method.
  • To assess the impact of HT-IMS on signal-to-noise ratio (SNR) and spectral resolution compared to traditional methods.

Main Methods:

  • Implementation of Hadamard transform (HT) for ion mobility spectrometry (IMS) data acquisition.
  • Utilizing a 50% duty cycle, a significant increase from the conventional ~1% duty cycle.

Related Experiment Videos

  • Acquisition of spectra for amphetamine and cytochrome c samples using both traditional and HT-IMS techniques.

    • Main Results:

    • The Hadamard transform ion mobility spectrometry (HT-IMS) technique demonstrated a 2-10 fold increase in signal-to-noise ratio (SNR).
    • No reduction in spectral resolution was observed with the HT-IMS method.
    • The enhanced duty cycle (50%) contributes to the improved SNR.

    Conclusions:

    • Hadamard transform (HT) offers a promising advancement in ion mobility spectrometry (IMS) data acquisition.
    • HT-IMS provides a substantial improvement in signal-to-noise ratio (SNR) without sacrificing spectral resolution.
    • This technique presents a viable alternative to traditional signal-averaged data acquisition in IMS.