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Dialysis in patients with upper urinary tract transitional cell carcinoma
R A Persad1, D A Gillatt, P Harrison
1Department of Urology, Royal Infirmary Hospital, Bristol.
British Journal of Urology
|June 1, 1992
Summary
Radical kidney cancer surgery may necessitate dialysis or transplantation. Patients undergoing bilateral nephrectomy for urothelial malignancy can achieve tumor-free survival on dialysis, supporting its use before potential kidney transplantation.
Area of Science:
- Nephrology
- Urology
- Oncology
Background:
- Radical surgery for primary kidney cancer can lead to renal failure, especially with bilateral tumors or solitary kidneys.
- The management of dialysis and transplantation post-cancer surgery in these specific cases remains unclear.
Observation:
- A literature review and case series of 4 patients undergoing bilateral nephrectomies for recurrent upper tract urothelial malignancy were analyzed.
- Patients were followed on dialysis after nephrectomy.
- Tumor recurrence status and survival were monitored.
Findings:
- All 4 patients remained tumor-free on dialysis at 5, 8, 12, and 72 months post-dialysis initiation.
- Two patients died from causes unrelated to their malignancy.
- No tumor recurrence was observed in the surviving patients during the follow-up period.
Implications:
- Dialysis followed by kidney transplantation is a reasonable approach for patients with bilateral kidney malignancy.
- A disease-free interval of 1-2 years post-surgery is suggested before transplantation.
- This strategy may offer a cure and improved survival for select patients with advanced kidney cancer.