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Related Experiment Videos

L1 immunoreactivity in the developing fish visual system.

E Blaugrund1, S Sharma, M Schwartz

  • 1Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel.

Brain Research
|March 6, 1992
PubMed
Summary
This summary is machine-generated.

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The cell adhesion molecule L1 is expressed by developing fish visual system neurons, particularly non-myelinated axons. This L1 expression is lost upon maturation and myelination, suggesting a role in regeneration.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cell Biology

Background:

  • Previous research indicated the presence of L1 cell adhesion molecule in regenerating fish optic nerves.
  • The role of L1 in developing neuronal structures, particularly in fish, requires further elucidation.

Purpose of the Study:

  • To investigate the expression of L1 by fish neurons, specifically in non-myelinated axons.
  • To determine the developmental expression pattern of L1 in the fish visual system.

Main Methods:

  • Utilized fish retinal explants for in vitro studies.
  • Examined the developing fish visual system in vivo.
  • Employed L1-like immunoreactivity staining to identify L1 expression sites.

Main Results:

Related Experiment Videos

  • In vitro, non-myelinated axons from retinal explants exhibited L1 immunoreactivity.
  • In vivo, L1 immunoreactive sites correlated with areas dense in non-myelinated axons during development.
  • L1 expression was observed in the optic nerve and retinal plexiform layers from embryonic stage 23 until hatching, decreasing with maturation and myelination.

Conclusions:

  • Non-myelinated axons in the developing fish visual system express L1.
  • L1 expression is transient, present during development and potentially reappearing during regeneration after being lost post-myelination.