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Updated: Aug 5, 2026
06:59
Nanomanipulation of Single RNA Molecules by Optical Tweezers
Published on: August 20, 2014
Coupled dynamics of RNA folding and nanopore translocation
Ralf Bundschuh1, Ulrich Gerland
1Department of Physics, The Ohio State University, Columbus, Ohio 43210-1117, USA.
Physical Review Letters
|December 31, 2005
Abstract:
The translocation of structured RNA or DNA molecules through narrow pores necessitates the opening of all base pairs. Here, we study the interplay between the dynamics of translocation and base pairing theoretically, using kinetic Monte Carlo simulations and analytical methods. We find that the transient formation of base pairs that do not occur in the ground state can significantly speed up translocation.
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