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Cutaneous angiolipoleiomyoma.
Eiichi Makino1, Jun Yamada, Joji Tada
1Department of Dermatology, Okayama University, Graduate School of Medicine and Dentistry, Okayama-shi, Japan. makinoh@cc.okayama-u.ac.jp
Journal of the American Academy of Dermatology
|December 31, 2005
Summary
A rare cutaneous angiolipoleiomyoma (CAL) was surgically removed from a 16-year-old girl. This benign mesenchymal tumor is distinct from its renal counterpart, particularly regarding tuberous sclerosis complex association.
Area of Science:
- Dermatology
- Pathology
- Oncology
Background:
- Angiomyolipoma (AML) is a rare benign mesenchymal tumor typically found in the kidney.
- Cutaneous AML (CAL), also known as cutaneous angiolipoleiomyoma, is an exceptionally rare variant.
Observation:
- A 16-year-old female presented with a tender, vascular subcutaneous tumor on her buttock.
- Surgical excision revealed a poorly circumscribed lesion composed of blood vessels, smooth muscle, and adipose tissue.
Findings:
- Histological examination confirmed the diagnosis of cutaneous angiomyolipoma.
- This case, along with a literature review of 16 others, highlights CAL as a distinct entity from renal AML.
- Key differences include associations with tuberous sclerosis complex and distinct immunoreactivity patterns (HMB-45, MART-1).
Implications:
- This case expands the understanding of rare cutaneous mesenchymal tumors.
- Distinguishing CAL from renal AML is crucial for accurate diagnosis and patient management.
- Further research into CAL's specific characteristics and associations is warranted.