Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Constitutional balanced translocations in patients with solid tumors.

F Richard1, M Muleris, J Couturier

  • 1CNRS URA 620, Institut Curie, Section de Biologie, Paris, France.

Cancer Genetics and Cytogenetics
|July 1, 1992
PubMed
Summary

Solid tumors in adults show a higher rate of balanced constitutional translocations than newborns. This study observed four translocations in 329 patients, indicating a potential link between these chromosomal abnormalities and cancer development.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A South American origin of the genus Dynastes (Coleoptera: Scarabaeidae: Dynastinae) demonstrated by chromosomal analyses.

Cytogenetic and genome research·2013
Same author

[Not Available].

Genetique, selection, evolution·2012
Same author

Low, complex and probably reticulated chromosome evolution of Sciuromorpha (Rodentia) and Lagomorpha.

Cytogenetic and genome research·2012
Same author

Chromosome analysis of 82 species of Scarabaeoidea (Coleoptera), with special focus on NOR localization.

Cytogenetic and genome research·2012
Same author

Cyclocephala (Coleoptera: Scarabaeidae: Dynastinae) evolution in Lesser West Indies indicates a Northward colonization by C. tridentata.

Bulletin of entomological research·2011
Same author

Glycolytic profile in normal brain tissue and gliomas determined by a micro-method analysis.

Oncology reports·2011

Area of Science:

  • Cytogenetics
  • Oncology
  • Human Genetics

Background:

  • Balanced constitutional translocations are chromosomal abnormalities present from birth.
  • The prevalence of these translocations in adult cancer patients is not well-established.
  • Previous studies have primarily focused on newborn screening for translocations.

Purpose of the Study:

  • To investigate the frequency of balanced constitutional translocations in adult patients diagnosed with solid tumors.
  • To compare the observed translocation rates in cancer patients with those found in newborn populations.

Main Methods:

  • Karyotyping was performed on a cohort of 329 patients with various solid tumors including colon and breast adenocarcinoma, cervical carcinoma, and meningioma.
  • Observed translocations were classified as either t(13q14q) or reciprocal translocations.

Related Experiment Videos

  • Data was compared with existing epidemiological surveys of chromosomal abnormalities in newborns.

    • Main Results:

    • Four balanced constitutional translocations were identified in the patient cohort.
    • Two instances of t(13q14q) and two reciprocal translocations were detected.
    • A statistically significant excess of translocations was observed in the solid tumor patient sample compared to newborn surveys.

    Conclusions:

    • Adults with solid tumors exhibit a higher prevalence of balanced constitutional translocations than the general newborn population.
    • These findings suggest a potential role for constitutional translocations in the predisposition to or development of certain solid tumors.
    • Further research is warranted to explore the specific mechanisms linking these chromosomal rearrangements to oncogenesis.